| 货号 | 12012-10mg |
| 描述 | Prostaglandin D2 ethanolamide (PGD2-EA) is a bioactive lipid produced by the sequential metabolism of anandamide (arachidonoyl ethanolamide) by cyclooxygenase (COX) enzymes, in particular by COX-2, and PGD synthase.1,2,3 The biosynthesis of PGD2-EA from anandamide can also be increased when anandamide metabolism is diminished by deletion of fatty acid amide hydrolase.4PGD2-EA is inactive against recombinant prostanoid receptors, including the D prostanoid receptor.5 It increases the frequency of miniature inhibitory postsynaptic currents in primary cultured hippocampal neurons, an effect which is the opposite of that induced by anandamide.3. PGD2-EA also induces apoptosis in colorectal carcinoma cell lines.2 |
| 别名 | PGD2-EA;Prostamide D2; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Kozak, K.R.,Crews, B.C.,Morrow, J.D., et al. Metabolism of the endocannabinoids, 2-arachidonylgycerol and anandamide, into prostaglandin, thromboxane, and prostacyclin glycerol esters and ethanolamides. The Journal of Biological Chemisty 277(47), 44877-44885 (2002). 2.Patsos, H.A.,Hicks, D.J.,Dobson, R.R.H., et al. The endogenous cannabinoid, anandamide, induces cell death in colorectal carcinoma cells: A possible role for cyclooxygenase 2. Gut 54(12), 1741-1750 (2005). 3.Sang, N.,Zhang, J., and Chen, C. PGE2 glycerol ester, a COX-2 oxidative metabolite of 2-arachidonoyl glycerol, modulates inhibitory synaptic transmission in mouse hippocampal neurons. Journal of Physiology 572, 735-745 (2006). 4.Weber, A.,Ni, J.,Ling, K.H.J., et al. Formation of prostamides from anandamide in FAAH knockout mice analyzed by HPLC with tandem mass spectrometry. Journal of Lipid Research 45, 757-763 (2004). 5.Matias, I.,Chen, J.,De Petrocellis, L., et al. Prostaglandin ethanolamides (prostamides): In vitro pharmacology and metabolism. Journal of Pharmacology and Experimental Therapeutics 309(2), 745-757 (2004). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥96% |
| 计算分子量 | 395.5 |
| 分子式 | C22H37NO5 |
| CAS号 | 398138-28-8 |
| 稳定性 | ≥ 1 year |
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