| 货号 | 4323/50 |
| 别名 | N-Cyclobutyl-6-[2-(3-fluorophenyl)e |
| 供应商 | Tocris |
| 生物活性 | Positive allosteric modulator of mGlu5 receptors (EC50 = 16 nM; Ki = 195 nM). Selective for mGlu5; displays no significant activity at mGlu1, mGlu2 or mGlu4 receptors. Exhibits antipsychotic-like activity in a rodent model. Also reduces spontaneous spike and wave discharges without affecting motor behaviour in a rat model of absence epilepsy. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 330.78 |
| 分子式 | C18H15FN2O.HCl |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO and to 25 mM in ethanol |
| 参考文献 | D'Amoreet al (2013) Potentiation of mGlu5 receptors with the novel enhancer, VU0360172, reduces spontaneous absence seizures in WAG/Rij rats. Neuropharmacology 66 330. PMID: 22705340. Rodriguezet al (2010) Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity. Mol.Pharmacol. 78 (6) 1105. PMID: 20923853. |