L-AP4
货号：
14538-50mg 基本售价：
8400.0 元 规格：
50 mg
产品信息
概述| 货号 | 14538-50mg |
| 描述 | Metabotropic glutamate receptors (mGluR) function to modulate excitatory synaptic transmission in the brain. Eight subtypes (1-8) and multiple splice variants of the mGluR have been identified and grouped based on their pharmacological properties. Group I mGluRs (subtypes 1 and 5) activate the phosphatidyl inositol pathway, while Group II (2 and 3) and Group III (4, 6, 7, and 8) inhibit adenylyl cyclase. L-AP4, an analog of L-glutamic acid, is a selective Group III mGluR agonist that functions presynaptically to suppress glutamate release (IC50 = 2.5 μM).1,2,3 L-AP4 has been shown to depress synaptic transmission in glutamatergic pathways in the hippocampus, olfactory bulb, and retina as well as act as an agonist at the quisqualate-sensitized AP6 site in hippocampus.1 |
| 别名 | L-(+)-2-amino-4-phosphorobutanoic acid;L-APB; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Thomsen, C. The L-AP4 receptor. Gen.Pharmac. 29(2), 151-158 (1997).
2.Evans, R.H.,Francis, A.A.,Jones, A.W., et al. The effects of a series of ω-phosphonic α-carboxylic amino acids on electrically evoked and excitant amino acid-induced responses in isolated spinal cord preparations. Br.J.Pharmac. 75, 65-75 (1982).
3.Schoepp, D.D. Unveiling the functions of presynaptic metabotropic glutamate receptors in the central nervous system. Journal of Pharmacology and Experimental Therapeutics 299(1), 12-20 (2001).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | 4 |
| 纯度 | ≥99% |
| 计算分子量 | 183.1 |
| 分子式 | C4H10NO5P |
| CAS号 | 23052-81-5 |
| 稳定性 | ≥ 6 months |
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