Apatinib
货号：
21268-50mg 基本售价：
8400.0 元 规格：
50 mg
产品信息
概述| 货号 | 21268-50mg |
| 描述 | Apatinib is a tyrosine kinase inhibitor that potently suppresses the kinase activity of vascular endothelial growth factor 2 (VEGFR2; IC50 = 1 nM).1 It is less effective against c-kit (IC50 = 429 nM), Ret (IC50 = 13 nM), and c-src (IC50 = 53 nM) and does not inhibit EGFR, Her-2, or FGFR1 (IC50s = >10 µM).1 Apatinib has been shown to inhibit the proliferation, migration, and tube formation of human umbilical vein endothelial cells stimulated by fetal bovine serum and, either alone, or in combination with chemotherapeutic agents, prevented the growth of several established human tumor xenograft models.1 |
| 别名 | YN968D1; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Tian, S.,Quan, H.,Xie, C., et al. YN968D1 is a novel and selective inhibitor of vascular endothelial growth factor receptor-2 tyrosine kinase with potent activity in vitro and in vivo. Cancer Sci. 102(7), 1374-1380 (2011).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 397.5 |
| 分子式 | C24H23N5O |
| CAS号 | 811803-05-1 |
| 稳定性 | ≥ 2 years |
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