PF-04708671
货号：
15018-100mg 基本售价：
8400.0 元 规格：
100 mg
产品信息
概述| 货号 | 15018-100mg |
| 描述 | P70 ribosomal S6 kinase (S6K1) is a serine/threonine kinase which is activated by insulin and growth factors through PI3K and mTORC1 signaling pathways. PF-04708671 is a specific, cell-permeable inhibitor of S6K1 (IC50 = 160 nM).1 It does not inhibit S6K2, MSK, or RSK, or many other unrelated kinases, under conditions in which it inhibits S6K1 activity.1 It is useful in evaluating the role of S6K1 and, indirectly, mTORC1, in cell signaling.2,3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Pearce, L.R.,Alton, G.R.,Richter, D.T., et al. Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1). Biochemistry Journal 431, 245-255 (2010).
2.Rajan, M.R.,Fagerholm, S.,Jönsson, C., et al. Phosphorylation of IRS1 at serine 307 in response to insulin in human adipocytes is not likely to be catalyzed by p70 ribosomal S6 kinase. PLoS One 8(4), (2013).
3.McNamara, C.R.,Ahuja, R.,Osafo-Addo, A.D., et al. Akt regulates TNFα synthesis downstream of RIP1 kinase activation during necroptosis. PLoS One 8(3), (2013).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 390.4 |
| 分子式 | C19H21F3N6 |
| CAS号 | 1255517-76-0 |
| 稳定性 | ≥ 2 years |
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