WIKI4
货号：
14057-50mg 基本售价：
8400.0 元 规格：
50 mg
产品信息
概述| 货号 | 14057-50mg |
| 描述 | Tankyrases (TNKS) cleave NAD+ to produce nicotinamide and ADP-ribose, which is then covalently attached to an acceptor protein in the process known as poly(ADP-ribosyl)ation. WIKI4 is a potent and selective inhibitor of TNKS1 and TNKS2 (IC50s = 26 and 15 nM, respectively).1,2 It has little or no effect on related polymerases or transferases at 10 µM.2 Through its effects on TNKS2, WIKI4 prevents AXIN ubiquitinylation and degradation, blocking signaling through the Wnt/β-catenin pathway.1 WIKI4 inhibits the expression of β-catenin target genes and cellular responses to Wnt/β-catenin signaling in both cancer cell lines and embryonic stem cells.1 |
| 别名 | Tankyrase 1/2 Inhibitor V; |
性能| 供应商 | Cayman |
| 应用文献 |
1.James, R.G.,Davidson, K.C.,Bosch, K.A., et al. WIKI4, a novel inhibitor of tankyrase and Wnt/β-catenin signaling. PLoS One 7(12), 1-10 (2012).
2.Haikarainen, T.,Venkannagari, H.,Narwal, M., et al. Structural basis and selectivity of tankyrase inhibition by a Wnt signaling inhibitor WIKI4. PLoS One 8(6), 1-8 (2013).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 521.6 |
| 分子式 | C29H23N5O3S |
| CAS号 | 838818-26-1 |
| 稳定性 | ≥ 2 years |
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