WYE-354
货号：
13604-50mg 基本售价：
8400.0 元 规格：
50 mg
产品信息
概述| 货号 | 13604-50mg |
| 描述 | WYE-354 is a potent cell-permeable inhibitor of mTOR (IC50 = 4.3 nM) which blocks signaling through both mTOR complex 1 (mTORC1) and mTORC2.1,2 It is a much weaker inhibitor of phosphatidylinositol 3-kinase α (IC50 = 1026 nM) and other kinases.3 WYE-354 induces G1 cell cycle arrest in both rapamycin-sensitive and rapamycin-resistant cancer cell lines, inhibits mTORC1 and mTORC2 in tumor-bearing mice, and reduces tumor growth in nude mice with PTEN-null tumors.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Yu, K.,Toral-Barza, L.,Shi, C., et al. Biochemical, cellular, and in vivo activity of novel ATP-competitive and selective inhibitors of the mammalian target of rapamycin. Cancer Research 69(15), 6232-6240 (2009).
2.Zhao, Y.,Wieman, H.L.,Jacobs, S.R., et al. Mechanisms and methods in glucose metabolism and cell death. Methods in Enzymology 442, 1-14 (2008).
3.Zask, A.,Verheijen, J.C.,Curran, K., et al. ATP-competitive inhibitors of the mammalian target of rapamycin: design and synthesis of highly potent selective pyrazolopyrimidines. Journal of Medicinal Chemistry 52, 5013-5016 (2009).
|
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 495.5 |
| 分子式 | C24H29N7O5 |
| CAS号 | 1062169-56-5 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
