| 货号 | 13313-50mg |
| 描述 | IKK-16 is a potent inhibitor of IκB kinases (IKKs), displaying IC50 values of 200, 40, and 70 nM for IKKα, IKKβ, and IKK complex, respectively, in cell-free assays.1 It is effective in cells and in animals and has been used delineate the role of NF-κB signaling in diverse contexts.2,3,4,5 IKK-16 has also been reported to inhibit protein kinase D isoforms and the ATP-binding cassette (ABC) transporter ABCB1.6,7 |
| 别名 | IKK Inhibitor VII; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Waelchli, R.,Bollbuck, B.,Bruns, C., et al. Design and preparation of 2-benzamido-pyrimidines as inhibitors of IKK. Bioorganic & Medicinal Chemistry Letters 16(1), 108-112 (2006). 2.Coldewey, S.M.,Rogazzo, M.,Collino, M., et al. Inhibition of I k B kinase reduces the multiple organ dysfunction caused by sepsis in the mouse. Dis.Model Mech. 6, 1031-1042 (2013). 3.Thein, S.,Pham, A.,Bayer, K.U., et al. IKK regulates the deubiquitinase CYLD at the postsynaptic density. Biochemical and Biophysical Research Communications 450(1), 550-554 (2014). 4.Fallahi-Sichani, M.,Moerke, N.J.,Niepel, M., et al. Systematic analysis of BRAFV600E melanomas reveals a role for JNK/c-Jun pathway in adaptive resistance to drug-induced apoptosis. Mol.Syst.Biol. 11, 797 (2015). 5.Sordi, R.,Chiazza, F.,Johnson, F.L., et al. Inhibition of I k B kinase attenuates the organ injury and dysfunction associated with hemorrhagic shock. Molecular Medicine (2015). 6.Tandon, M.,Johnson, J.,Li, Z., et al. New pyrazolopyrimidine inhibitors of protein kinase d as potent anticancer agents for prostate cancer cells. PLoS One 8(9), e75601 (2013). 7.Ansbro, M.R.,Shukla, S.,Ambudkar, S.V., et al. Screening compounds with a novel high-throughput ABCB1-mediated efflux assay identifies drugs with known therapeutic targets at risk for multidrug resistance interference. PLoS One 8(4), e60334 (2013). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 520.1 |
| 分子式 | C28H29N5OS • HCl |
| CAS号 | 1186195-62-9 |
| 稳定性 | ≥ 2 years |
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