| 货号 | 16412-500mg |
| 描述 | Hexanoyl glycine is an acylated amino acid that is used as a urinary biomarker for several indications. It is normally biosynthesized from hexanoyl-CoA and glycine by the mitochondrial enzyme glycine N-acyltransferase. Increased urinary excretion of hexanoyl glycine in humans is indicative of a deficiency in medium-chain acyl-CoA dehydrogenase.1,2 Increased urinary hexanoyl glycine can also be used as a biomarker for exposure to gamma radiation.3 Levels of hexanyl glycine can also be elevated during cancer, while they are decreased 20-fold in mice following treatment with the PPARα ligand Wy 14643(Item No. 70730).4,5 |
| 别名 | NSC 224460; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Rinaldo, P.,OShea, J.J.,Coates, P.M., et al. Medium-chain acyl-CoA dehydrogenase deficiency. Diagnosis by stable-isotope dilution measurement of urinary n-hexanoylglycine and 3-phenylpropionylglycine. New England Journal of Medicine 319(20), 1308-1313 (1988). 2.Tserng, K.Y.,Jin, S.J.,Kerr, D.S., et al. Abnormal urinary excretion of unsaturated dicarboxylic acids in patients with medium-chain acyl-CoA dehydrogenase deficiency. Journal of Lipid Research 31(5), 763-761 (1990). 3.Tyburski, J.B.,Patterson, A.D.,Krausz, K.W., et al. Radiation metabolomics: Identification of minimally invasive urine biomarkers for gamma-radiation exposure in mice. Radiation Research 170(1), 1-14 (2008). 4.Li, F.,Patterson, A.D.,Krausz, K.W., et al. Metabolomics reveals that tumor xenografts induce liver dysfunction. Mol.Cell.Proteomics 12(8), 2126-2135 (2013). 5.Zhen, Y.,Krausz, K.W.,Chen, C., et al. Metabolomic and genetic analysis of biomarkers for PPARα expression and activation. Molecular Endocrinology 21(9), 2136-2151 (2007). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 173.2 |
| 分子式 | C8H15NO3 |
| CAS号 | 24003-67-6 |
| 稳定性 | ≥ 2 years |
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