HPI-1
货号：
15221-50mg 基本售价：
8302.0 元 规格：
50 mg
产品信息
概述| 货号 | 15221-50mg |
| 描述 | HPI-1 is a Hedgehog (Hh) pathway inhibitor that suppresses signaling through Sonic Hh (IC50 = 1.5 µM) without significantly affecting Wnt signaling (IC50 ≥ 30 µM).1 HPI-1 suppresses Hh activation induced by loss of Suppressor of Fused or by Gli overexpression, suggesting action at posttranslational modification of Gli protein or at the interaction of Gli with a co-factor.1 HPI-1 also inhibits signaling through the oncogenic Smoothened (Smo) mutant SmoM2 in neuron precursors, preventing cell proliferation.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Hyman, J.M.,Firestone, A.J.,Heine, V.M., et al. Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade. Proceedings of the National Academy of Sciences of the United States of America 106(33), 14132-14137 (2009).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 463.5 |
| 分子式 | C27H29NO6 |
| CAS号 | 599150-20-6 |
| 稳定性 | ≥ 2 years |
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