TCS-OX2-29
货号：
17419-50mg 基本售价：
8288.0 元 规格：
50 mg
产品信息
概述| 货号 | 17419-50mg |
| 描述 | Orexin receptors R1 (OX1R) and OX2R mediate the action of the neuropeptides orexin A and orexin B. TCX-OX2-29 is an antagonist of OX2R (pKi = 7.5) that exhibits >250-fold selectivity for hOX2R compared with hOX1R (IC50s = 40 nM and >10,000 nM, respectively).1,2 It blocks the inhibitory action of orexin A on forskolin-induced cAMP formation.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Mould, R.,Brown, J.,Marshall, F.H., et al. Binding kinetics differentiates functional antagonism of orexin-2 receptor ligands. British Journal of Pharmacology 171(2), 351-363 (2014).
2.Hirose, M.,Egashira, S.i.,Goto, Y., et al. N-acyl 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline: The first orexin-2 receptor selective non-peptidic antagonist. Bioorganic & Medicinal Chemistry Letters 13(24), 4497-4499 (2003).
3.Urbanska, A.,Sokolowska, P.,Woldan-Tambor, A., et al. Orexins/hypocretins acting at Gi protein-coupled OX 2 receptors inhibit cyclic AMP synthesis in the primary neuronal cultures. Journal of Molecular Neuroscience 46(1), 10-17 (2012).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 434 |
| 分子式 | C23H31N3O3 • HCl |
| CAS号 | 1610882-30-8 |
| 稳定性 | ≥ 2 years |
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