PKA Inhibitor Fragment (6-22) amide
货号：
17486-10mg 基本售价：
8260.0 元 规格：
10 mg
产品信息
概述| 货号 | 17486-10mg |
| 描述 | PKA inhibitor fragment (6-22) amide is a synthetic peptide inhibitor of cAMP-dependent protein kinase (PKA; Ki = 1.7 nM) derived from the heat-stable PKA inhibitor protein PKI.1 It is the shortest synthetic PKI peptide that retains high potency for PKA inhibition. Both the arginine-containing pseudosubstrate site of the PKI peptide in its COOH terminus and the residue Phe10 in NH2-terminal portion are required for this high affinity binding.2 |
| 别名 | PKI (6-22) amide; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Glass, D.B.,Cheng, H.C.,Mende-Mueller, L., et al. Primary structural determinants essential for potent inhibition of cAMP-dependent protein kinase by inhibitory peptides corresponding to the active portion of the heat-stable inhibitor protein. The Journal of Biological Chemisty 264(15), 8802-8810 (1989).
2.Glass, D.B.,Lundquist, L.J.,Katz, B.M., et al. Protein kinase inhibitor-(6-22)-amide peptide analogs with standard and nonstandard amino acid substitutions for phenylalanine 10. Inhibition of cAMP-dependent protein kinase. The Journal of Biological Chemisty 264(24), 14579-14584 (1989).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 计算分子量 | 1868.1 |
| 分子式 | C80H130N28O24 |
| CAS号 | 121932-06-7 |
| 稳定性 | ≥ 2 years |
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