| 货号 | 15431-50mg |
| 描述 | Picroliv is a hepatoprotective mixture of compounds that is isolated from an herb native to the Himalayas.1 Picroside I is an iridoid glycoside found in picroliv.1 By itself, picroside I blocks changes in acid phosphatase activity, phospholipid levels, and lipid peroxide production induced by D-galactosamine in rat liver.2 Picroside I also enhances neurite outgrowth in PC12D cells induced by basic fibroblast growth factor and 7S nerve growth factor when given at 60 μM.3,4 At concentrations as low as 5 μM, picroside I enhances the ATPase activity of the efflux transporter P-glycoprotein.5 |
| 别名 | 6’-Cinnamoylcatalpol; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Girish, C. and Pradhan, S.C. Drug development for liver diseases: Focus on picroliv, ellagic acid and curcumin. Fundamental Clinical Pharmacology 22, 623-632 (2008). 2.Dwivedi, Y.,Rastogi, R.,Garg, N.K., et al. Picroliv and its components kutkoside and picroside I protect liver against galactosamine-induced damage in rats. Pharmacology & Toxicology 71, 383-387 (1992). 3.Li, P.,Matsunaga, K.,Yamakuni, T., et al. Potentiation of nerve growth factor-action by picrosides I and II, natural iridoids, in PC12D cells. European Journal of Pharmacology 406(2), 203-208 (2000). 4.Li, P.,Matsunaga, K.,Yamakuni, T., et al. Picrosides I and II, selective enhancers of the mitogen-activated protein kinase-dependent signaling pathway in the action of neuritogenic substances on PC12D cells. Life Sciences 71(15), 1821-1835 (2002). 5.Najar, I.A.,Sachin, B.S.,Sharma, S.C., et al. Modulation of P-glycoprotein ATPase activity by some phytoconstituents. Phytotherapy Research 24(3), 454-458 (2010). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 492.5 |
| 分子式 | C24H28O11 |
| CAS号 | 27409-30-9 |
| 稳定性 | ≥ 2 years |
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