1400W (hydrochloride)
货号：
81520-100mg 基本售价：
8232.0 元 规格：
100 mg
产品信息
概述| 货号 | 81520-100mg |
| 描述 | 1400W is a potent, selective inhibitor of iNOS.1 Using purified human iNOS, nNOS, and eNOS, 1400W exhibits Ki values of 7 nM, 2 µM, and 50 µM, respectively.1 In rat aortic rings it is at least 1,000-fold more potent against iNOS compared to eNOS.1 In mice bearing a murine mammary carcinoma, continuous infusion of 1400W at a rate of 10 mg/kg for 6 days decreased tumor weight approximately 50% compared to controls.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Garvey, E.P.,Oplinger, J.A.,Furfine, E.S., et al. 1400W is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo. The Journal of Biological Chemisty 272, 4959-4963 (1997).
2.Thomsen, L.L.,Scott, J.M.J.,Topley, P., et al. Selective inhibition of inducible nitric oxide synthase inhibits tumor growth in vivo: Studies with 1400W, a novel inhibitor. Cancer Research 57, 3300-3304 (1997).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 250.2 |
| 分子式 | C10H15N3 • 2HCl |
| CAS号 | 214358-33-5 |
| 稳定性 | ≥ 1 year |
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