6-Formylindolo[3,2-b]carbazole
货号：
19529-10mg 基本售价：
8232.0 元 规格：
10 mg
产品信息
概述| 货号 | 19529-10mg |
| 描述 | 6-Formylindolo[3,2-b]carbazole (FICZ) is a degradation product of tryptophan upon exposure to visible light that activates the aryl hydrocarbon receptor (AhR; Kd = 70 pM).1 This endogenous AhR ligand is also a good substrate for cytochromes P450 (CYP) 1A1, 1A2, and 1B1 (Kis = 15.4, 3.9, and 13.3 µM, respectively).2 When activated by either environmental toxins or endogenous ligands, the AhR induces detoxifying enzymes and modulates immune cell differentiation. FICZ has been used to study the immunomodulatory and host defense mechanisms of AhR signaling pathways.3 |
| 别名 | FICZ; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Rannug, U.,Rannug, A.,Sjöberg, U., et al. Structure elucidation of two tryptophan-derived, high affinity Ah receptor ligands. Chem.Biol. 2(12), 841-845 (1995).
2.Wincent, E.,Amini, N.,Leuecke, S., et al. The suggested physiologic aryl hydrocarbon receptor activator and cytochrome P4501 substrate 6-formylindolo[3,2-b]carbazole is present in humans. J.Biol.Chem. 284(5), 2690-2696 (2009).
3.Moura-Alves, P.,Faé, K.,Houthuys, E., et al. AhR sensing of bacterial pigments regulates antibacterial defence. Nature 512(7515), 387-392 (2014).
|
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 284.3 |
| 分子式 | C19H12N2O |
| CAS号 | 172922-91-7 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
