4,4-Dicyanobenzhydrol
货号：
21316-50mg 基本售价：
8218.0 元 规格：
50 mg
产品信息
概述| 货号 | 21316-50mg |
| 描述 | 4,4-Dicyanobenzhydrol is a major oxidative metabolite of letrozole (Item No. 11568).1 Letrozole is a potent, cell-permeable inhibitor of aromatase (IC50 = 2 nM), a cytochrome P450 family member (designated CYP19) which catalyzes the conversion of androgens to estrogens.2,3 4,4-Dicyanobenzhydrol is a weak inhibitor of CYP2B6 and CYP2C19 (Kis = 40 and 4.5 µM in vitro, respectively).1 |
| 别名 | bis-(4-Cyanophenyl)methanol;bis(p-Cyanophenyl)methanol;CGP 44,645; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Jeong, S.,Woo, M.M.,Flockhart, D.A., et al. Inhibition of drug metabolizing cytochrome P450s by the aromatase inhibitor drug letrozole and its major oxidative metabolite 4,4-methanol-bisbenzonitrile in vitro. Cancer Chemother. Pharmacol. 64(5), 867-875 (2009).
2.Buzdar, A.U.,Robertson, J.F.R.,Eiermann, W., et al. An overview of the pharmacology and pharmacokinetics of the newer generation aromatase inhibitors anastrozole, letrozole, and exemestane. Cancer 95(9), 2006-2016 (2002).
3.Mayhoub, A.S.,Marler, L.,Kondratyuk, T.P., et al. Optimization of the aromatase inhibitory activities of pyridylthiazole analogues of resveratrol. Bioorganic & Medicinal Chemistry 20(7), 2427-2434 (2012).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 234.3 |
| 分子式 | C15H10N2O |
| CAS号 | 134521-16-7 |
| 稳定性 | ≥ 2 years |
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