5,6-dihydro-5-Fluorouracil
货号：
20977-50mg 基本售价：
8218.0 元 规格：
50 mg
产品信息
概述| 货号 | 20977-50mg |
| 描述 | 5,6-dihydro-5-Fluorouracil (5-FUH2) is formed by the hydrogenation of 5-fluorouracil (5-FU; Item No. 14416)via the enzyme dihydropyrimidine dehydrogenase (DPD).1 Formulations containing 5-FU are used for the treatment of cancer. However, in patients lacking full DPD activity, severe adverse events, including death, can occur. 5-FUH2 is less toxic than 5-FU but is not as effective (IC50s = 3.3 and 560 µM for 5-FU and 5-FUH2, respectively in WiDr human colon cancer cells).2 |
| 别名 | 5-DHFU;5-Fluorodihydropyrimidine-2,4-dione;5-Fluorodihydrouracil;5-Fluoro-5,6-dihydrouracil;5-FUH2; |
性能| 供应商 | Cayman |
| 应用文献 |
1.LaFrate, A.L. and Katzenellenbogen, J.A. Improved chemical syntheses of 5,6-dihydro-5-fluorouracil. J. Org. Chem. 72(22), 8573-8576 (2007).
2.Fischel, J.-L.,Formento, P.,Ciccolini, J., et al. Lack of contribution of dihydrofluorouracil and α-fluoro-β-alanine to the cytotoxicity of 5-deoxy-5-fluorouridine on human keratinocytes. Anticancer Drugs 15(10), 969-974 (2004).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 132.1 |
| 分子式 | C4H5FN2O2 |
| CAS号 | 696-06-0 |
| 稳定性 | ≥ 2 years |
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