| 货号 | 19601-50mg |
| 描述 | Eupatilin is an O-methylated flavone derived from Artemisia plants that demonstrates anti-inflammatory, anti-oxidative, and anti-tumor effects. It has been shown to induce apoptosis and cell cycle arrest at the G2/M phase in human A375 melanoma cells.1 It is also reported to protect gastric epithelial cells from oxidative damage by down-regulating certain genes responsible for cellular oxidative stress.2 Furthermore, eupatilin has been identified as a selective PPARα agonist (IC50 = 1.18 µM) as well as an inhibitor of 5-lipoxygenase (IC50 = 14 µM).3,4 |
| 别名 | NSC 122413; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Shawi, A.A.,Rasul, A.,Khan, M., et al. Eupatilin: A flavonoid compound isolated from the artemisia plant, induces apoptosis and G2/M phase cell cycle arrest in human melanoma A375 cells. Afr.J.Pharm.and Pharmacol. 5(5), 582-588 (2011). 2.Choi, E.J.,Oh, H.M.,Na, B.R., et al. Eupatilin protects gastric epithelial cells from oxidative damage and down-regulates genes responsible for the cellular oxidative stress. Pharmaceutical Research 25(6), 1355-1364 (2008). 3.Choi, Y.,Jung, Y., and Kim, S.N. Identification of eupatilin from Artemisia argyi as a selective PPARα agonist using affinity selection ultrafiltration LC-MS. Molecules 20(8), 13753-13763 (2015). 4.Koshihara, Y.,Neichi, T.,Murota, S.i., et al. Selective inhibition of 5-lipoxygenase by natural compounds isolated from Chinese plants, Artemisia rubripes Nakai. FEBS Letters 158(1), 41-44 (1983). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 344.3 |
| 分子式 | C18H16O7 |
| CAS号 | 22368-21-4 |
| 稳定性 | ≥ 2 years |
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