ML355
货号：
18537-25mg 基本售价：
8190.0 元 规格：
25 mg
产品信息
概述| 货号 | 18537-25mg |
| 描述 | Platelet-type 12-lipoxygenase (12-LO; Item No. 10341) catalyzes the formation of 12-HpETE (Item No. 44570) from arachidonic acid (Item No. 90010).1 It has been found to be expressed in various tumor cells as well as pancreatic islets and can be activated by inflammatory cytokines.2 It has also been implicated in the modulation of hemostasis and thrombosis through its role in regulating platelet function.2 ML355 is a selective inhibitor of 12-LO with an IC50 value of 0.34 µM.2 It demonstrates greatly reduced potency for 15-LO-1, 15-LO-2, and 5-LO (IC50s = 9.7, >100, and >100 µM) and no inhibition of COX-1 and -2.2 In cell-based assays, ML355 has been shown to decrease calcium mobilization and thrombin receptor PAR4-induced platelet aggregation in patient-derived human platelets and to significantly inhibit arachidonic acid and calcium- ionophore-induced 12-HpETE synthesis in mouse BTC3 cells and human islets.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Chen, X.S.,Kurre, U.,Jenkins, N.A., et al. cDNA cloning, expression, mutagenesis of C-terminal isoleucine, genomic structure, and chromosomal localizations of murine 12-lipoxygenases. The Journal of Biological Chemisty 269, 13979-13987 (1994).
2.Luci, D.K.,Jameson, J.B., II,Yasgar, A., et al. Synthesis and structure-activity relationship studies of 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase. Journal of Medicinal Chemistry 57(2), 495-506 (2014).
|
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 441.5 |
| 分子式 | C21H19N3O4S2 |
| CAS号 | 1532593-30-8 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
