| 货号 | 17768-100mg |
| 描述 | SMER28 is a small-molecule enhancer (SMER) of autophagy, inducing autophagy independently of rapamycin in mammalian cells when supplied at 47 µM.1 It increases autophagosome synthesis and enhances clearance of aggregate-prone substrates, including those relevant to Huntington’s, Parkinson’s, and Alzheimer’s diseases.1,2,3 SMER28 promotes reprogramming of fibroblasts into neural stem cells when used in combination with other chemical reagents.4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Sarkar, S.,Perlstein, E.O.,Imarisio, S., et al. Small molecules enhance autophagy and reduce toxicity in Huntington’s disease models. Nature Chemical Biology 3(6), 331-338 (2007). 2.Renna, M.,Jiminez-Sanchez, M.,Sarkar, S., et al. Chemical inducers of autophagy that enhance the clearance of mutant proteins in neurodegenerative diseases. The Journal of Biological Chemisty 285(15), 11061-11067 (2010). 3.Shen, D.,Coleman, J.,Chan, E., et al. Novel cell- and tissue-based assays for detecting misfolded and aggregated protein accumulation within aggresomes and inclusion bodies. Cell Biochemistry and Biophysics 60(3), 173-185 (2011). 4.Zhang, M.,Lin, Y.H.,Sun, Y.J., et al. Pharmacological reprogramming of fibroblasts into neural stem cells by signaling-directed transcriptional activation. Cell Stem Cell Apr, (2016). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 264.1 |
| 分子式 | C11H10BrN3 |
| CAS号 | 307538-42-7 |
| 稳定性 | ≥ 2 years |
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