| 货号 | 16121-5mg |
| 描述 | 3-Iodothyronamine is derived from the deiodination and decarboxylation of endogenous thyroxine. It activates the G protein-coupled receptor known as trace amine-associated receptor 1 at nanomolar concentrations whereupon it rapidly influences thyroid hormone actions including body temperature, heart rate, and cardiac output.1,2 It has also been reported to function in controlling lipid and glucose utilization, hormonal secretion, and neuronal function, and has been considered for use in chemically-induced hibernation for medical purposes.3,4,5 |
| 别名 | T1AM; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Zucchi, R.,Chiellini, G.,Scanlan, T.S., et al. Trace amine-associated receptors and their ligands. British Journal of Pharmacology 149(8), 967-978 (2006). 2.Chiellini, G.,Frascarelli, S.,Ghelardoni, S., et al. Cardiac effects of 3-iodothyronamine: A new aminergic system modulating cardiac function. The FASEB Journal 21(7), 1597-1608 (2007). 3.Manni, M.E.,De Siena, G.,Saba, A., et al. 3-Iodothyronamine: A modulator of the hypothalamus-pancreas-thyroid axes in mice. British Journal of Pharmacology 166(2), 650-658 (2012). 4.Braulke, J.,Klingenspor, M.,DeBarber, A., et al. 3-Iodothyronamine: A novel hormone controlling the balance between glucose and lipid utilisation. Journal of Comparative Physiology.B, Biochemical, Systemic, and Environmental Physiology 178(2), 167-177 (2008). 5.Kim, J.G.,Song, Y.K.,Jo, Y.H., et al. A new efficient synthetic method for 3-iodothyronamine involving sonication and its potent hypothermic efficacy. Bulletin of the Korean Chemical Society 32(4), 1131-1132 (2011). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 391.6 |
| 分子式 | C14H14INO2 • HCl |
| CAS号 | 788824-64-6 |
| 稳定性 | ≥ 2 years |
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