HDAC6 Inhibitor
货号：
15200-10mg 基本售价：
8190.0 元 规格：
10 mg
产品信息
概述| 货号 | 15200-10mg |
| 描述 | HDAC6 is a predominantly cytoplasmic enzyme that targets α-tubulin, cortactin, and heat shock protein 90, as well as other substrates.1 In this way, it impacts development, proliferation, invasion, and tumorigenesis.1 HDAC6 Inhibitor is a potent and selective inhibitor of HDAC6 (IC50 = 36 nM) that poorly blocks other HDAC enzymes.2 It is cell permeable, inhibiting the acetylation of tubulin in cells with an IC50 value of 210 nM.2 |
| 别名 | Histone Deacetylase 6; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Yang, P.H.,Zhang, L.,Zhang, Y.J., et al. HDAC6: Physiological function and its selective inhibitors for cancer treatment. Drug Discov.Ther. 7(6), 233-242 (2013).
2.Blackburn, C.,Barrett, C.,Chin, J., et al. Potent histone deacetylase inhibitors derived from 4-(aminomethyl)-N-hydroxybenzamide with high selectivity for the HDAC6 isoform. Journal of Medicinal Chemistry 56(18), 7201-7211 (2013).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 299.3 |
| 分子式 | C16H17N3O3 |
| CAS号 | 1259296-46-2 |
| 稳定性 | ≥ 1 year |
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