| 货号 | 14580-50mg |
| 描述 | A-438079 is a competitive antagonist of the nucleotide receptor P2X7(pIC50 = 6.9).1 It inhibits both calcium flux and IL-1β release mediated by P2X7 while not affecting the activity of other P2X receptors.1,2 A-438079 is effective in evaluating the role of P2X7 in nociception, oxidative stress, and apoptosis in cells and animals.3,4,5 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Nelson, D.W.,Gregg, R.J.,Kort, M.E., et al. Structure-activity relationship studies on a series of novel, substituted 1-benzyl-5-phenyltetrazole P2X7 antagonists. Journal of Medicinal Chemistry 49(12), 3659-3666 (2006). 2.Donnelly-Roberts, D.L. and Jarvis, M.F. Discovery of P2X7 receptor-selective antagonists offers new insights into P2X7 receptor function and indicates a role in chronic pain states. British Journal of Pharmacology 151(5), 571-579 (2007). 3.McGaraughty, S.,Chu, K.L.,Namovic, M.T., et al. P2X7-related modulation of pathological nociception in rats. Neuroscience 146(4), 1817-1828 (2007). 4.Haanes, K.A.,Schwab, A. and Novak, I. The P2X7 receptor supports both life and death in fibrogenic pancreatic stellate cells. PLoS One 7(12), (2012). 5.Bartlett, R.,Yerbury, J.J. and Sluyter, R. P2X7 receptor activation induces reactive oxygen species formation and cell death in murine EOC13 microglia. Mediators of Inflammation 2013, (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | 22 |
| 纯度 | ≥98% |
| 计算分子量 | 342.6 |
| 分子式 | C13H9Cl2N5 • HCl |
| CAS号 | 899431-18-6 |
| 稳定性 | ≥ 6 months |
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