| 货号 | 2463/50 |
| 别名 | 2-(2-Furanyl)-7-[3-(4-methoxyphenyl |
| 供应商 | Tocris |
| 生物活性 | Selective adenosine A2A receptor antagonist; binds to human and rat A2A receptors with high affinity (Ki values are 0.048 and 0.5 nM respectively). Displays > 23000-fold selectivity for hA2A over hA1in vitro with minimal affinity for hA2B and hA3 receptors (IC50 > 10 μM). Blocks the cytoprotective effect of A2A agonist CGS-21680 (Cat.No. 1063). |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 389.42 |
| 分子式 | C20H19N7O2 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 316173-57-6 |
| 参考文献 | Zhenget al (2007) Protective roles of adenosine A1, A2, and A3 receptors in skeletal muscle ischemia and reperfusion injury. Am.J.Physiol.Heart Circ.Physiol. 2933685. Toddeet al (2000) Design, radiosynthesis, and biodistribution of a new potent and selective ligand for in vivo imaging of the adenosine A2A receptor system using positron emission tomography. J.Med.Chem. 43 4359. PMID: 11087559. |