Ro 90-7501
货号：
18881-50mg 基本售价：
8176.0 元 规格：
50 mg
产品信息
概述| 货号 | 18881-50mg |
| 描述 | Ro 90-7501 is a bi-benzimidazole compound that was first found to retard the formation of mature amyloid β42 fibrils in a cell-based assay.1 Instead, extended polymeric sheets and fibrillary intermediates of amyloid β42 accumulated in response to Ro 90-7501 treatment, resulting in reduced cytotoxicity (EC50 = 2 µM).1 More recently, Ro 90-7501 was shown to modulate signaling in cells stimulated with polyinosinic-polycytidylic acid (poly(I:C); Item No. 16881), a toll-like receptor 3 (TLR3), and RIG-1-like receptor agonist.2 Ro 90-7501 (10 µM) enhanced poly(I:C)-induced IFN-β expression, decreased NF-κB activation, and amplified the suppression of vesicular stomatitis virus replication by poly(I:C) in HEK293 cells expressing TLR3.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Bohrmann, B.,Adrian, M.,Dubochet, J., et al. Self-assembly ofβamyloid 42 is retarded by small molecular ligands at the stage of structural intermediates. Journal of Structural Biology 130(2-3), 232-246 (2000).
2.Guo, F.,Mead, J.,Aliya, N., et al. RO 90-7501 enhances TLR3 and RLR agonist induced antiviral response. PLoS One 7(10), (2012).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 340.4 |
| 分子式 | C20H16N6 |
| CAS号 | 293762-45-5 |
| 稳定性 | ≥ 2 years |
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