| 货号 | 18599-50mg |
| 描述 | The amino acid γ-aminobutyric acid (GABA) is an inhibitory neurotransmitter that acts through two families of heteromeric ligand-gated ion channels, GABAA and GABAC, and a G protein-coupled receptor, GABAB. CGP 35348 is a selective, brain-accessible GABAB receptor antagonist (IC50 = 34 µM).1 It blocks the action of the GABAB-selective agonist baclofen (Item No. 18600) at postsynaptic sites but not at presynaptic receptors.1,2 CGP 35348 prevents baclofen-induced antinociception and muscle relaxation in mice and rats.3 It is commonly used to investigate the role of GABAB activation in neurological signaling.4,5,6 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Olpe, H.R.,Karlsson, G.,Pozza, M.F., et al. CGP 35348: A centrally active blocker of GABA B receptors. European Journal of Pharmacology 18791), 27-38 (1990). 2.Hills, J.M.,Larkin, M.M., and Howson, W. A comparison of the relative activities of a number of GABAB antagonists in the isolated vas deferens of the rat. British Journal of Pharmacology 102(3), 631-634 (1991). 3.Malcangio, M.,Ghelardini, C.,Giotti, A., et al. CGP 35348, a new GABAB antagonist, prevents antinociception and muscle-relaxant effect induced by baclofen. British Journal of Pharmacology 103(2), 1303-1308 (1991). 4.Koek, W.,Cheng, J., and Rice, K.C. Discriminative stimulus effects of the GABAB receptor-positive modulator rac-BHFF: Comparison with GABAB receptor agonists and drugs of abuse. Journal of Pharmacology and Experimental Therapeutics 344(3), 553-560 (2013). 5.Gillani, Q.,Ali, M., and Iqbal, F. CGP 35348, GABAB receptor antagonist, has a potential to improve neuromuscular coordination and spatial learning in albino mouse following neonatal brain damage. Biomed.Res.Int. 2014: 295215, (2014). 6.Ding, L.,Gao, R.,Xiong, X.Q., et al. GABA in paraventricular nucleus regulates adipose afferent reflex in rat. PLoS One 10(8), (2015). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | 4 |
| 计算分子量 | 225.2 |
| 分子式 | C8H20NO4P |
| CAS号 | 123690-79-9 |
| 稳定性 | ≥ 1 year |
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