| 货号 | 15190-50mg |
| 描述 | The sphingosine 1-phosphate (S1P) receptor S1P3 has roles in vasodilation, epithelial barrier function, cardioprotection, fibrosis, immunity, and inflammation.1,2 CYM 5541 is a selective, allosteric agonist of S1P3(EC50 = 72-132 nM).3,4 It less effectively activates S1P1(EC50 = 28-38 µM) and is ineffective at S1P2, S1P4, and S1P5 as well as a panel of other receptors, ion channels and transporters.3 |
| 别名 | CID-17253208;ML-249; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Choi, J.W.,Lee, C.W. and Chun, J. Biological roles of lysophospholipid receptors revealed by genetic null mice: An update. Biochimica et Biophysica Acta 1781, 531-539 (2008). 2.Rosen, H.,Stevens, R.C.,Hanson, M., et al. Sphingosine-1-phosphate and its receptors: Structure, signaling, and influence. Annual Reviews of Biochemistry 82, 637-662 (2013). 3.Guerrero, M.,Poddutoori, R.,Pinacho-Crisostomo, F., et al. Probe development efforts for an allosteric agonist of the sphingosine 1-phosphate receptor 3 (S1P3). 1-13 (2011). 4.Jo, E.,Bhhatarai, B.,Repetto, E., et al. Novel selective allosteric and bitopic ligands for the S1P3 receptor. ACS Chemical Biology 7(12), 1975-1983 (2012). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 316.4 |
| 分子式 | C19H28N2O2 |
| CAS号 | 945128-26-7 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |