| 货号 | 18862-50mg |
| 描述 | MMPIP is a reversible allosteric antagonist of the metabotropic glutamate receptor 7 (mGluR7) that blocks agonist-induced calcium mobilization (IC50 = 26 nM).1,2 It does not affect other mGlu receptors. The modulation of mGluR7 by MMPIP is context dependent, in that it is not observed in all known mGluR7 signaling pathways.2 MMPIP has been used to investigate the role of mGluR7 in cocaine-mediated reward signaling, attention and impulse control, and cognitive behavior in mice and rats.3,4,5 MMPIP also reversibly inhibits constitutive activity of mGluR7 in sympathetic neurons from the rat superior cervical ganglion.6 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Suzuki, G.,Tsukamoto, N.,Fushiki, H., et al. In vitro pharmacological characterization of novel isoxazolopyridone derivatives as allosteric metabotropic glutamate receptor 7 antagonists. Journal of Pharmacology and Experimental Therapeutics 323(1), 147-156 (2007). 2.Niswender, C.M.,Johnson, K.A.,Miller, N.R., et al. Context-dependent pharmacology exhibited by negative allosteric modulators of metabotropic glutamate receptor 7. Molecular Pharmacology 77(3), 459-468 (2010). 3.Li, X.,Li, J.,Peng, X.Q., et al. Metabotropic glutamate receptor 7 modulates the rewarding effects of cocaine in rats: Involvement of a ventral pallidal GABAergic mechanism. Neuropsychopharmacology 34(7), 1783-1796 (2009). 4.Benn, A. and Robinson, E.S.J. Investigating glutamatergic mechanism in attention and impulse control using rats in a modified 5-choice serial reaction time task. PLoS One 9(12), (2014). 5.Palazzo, E.,Romano, R.,Luongo, L., et al. MMPIP, an mGluR7-selective negative allosteric modulator, alleviates pain and normalizes affective and cognitive behavior in neuropathic mice. Pain 156(6), 1060-1073 (2015). 6.Kammemeier, P.J. Constitutive activity of metabotropic glutamate receptor 7. BMC Neuroscience 16:17, (2015). | |
| 运输条件 | Ambient in continental US; may vary elsewhere |
| 存放说明 | 22 |
| 纯度 | ≥98% |
| 计算分子量 | 369.8 |
| 分子式 | C19H15N3O3 • HCl |
| CAS号 | 1215566-78-1 |
| 稳定性 | ≥ 1 year |
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