PHTPP
货号：
16025-50mg 基本售价：
8064.0 元 规格：
50 mg
产品信息
概述| 货号 | 16025-50mg |
| 描述 | PHTPP is a pyrazolo[1,5-α]pyrimidine-based ligand that acts as a full antagonist of estrogen ERβ receptors with 36-fold selectivity over ERα.1 It exhibits no significant agonism on ERα or ERβ.1 This compound has been used to selectively target ERβ in the study of the opposing effects of hormone therapy on tumors expressing either ER subtype. At 100 pM, PHTPP has been found to enhance SKOV3 and OV2008 ovarian cancer cell growth in in vitroassays.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Compton, D.R.,Sheng, S.,Carlson, K.E., et al. Pyrazolo[1,5-a]pyrimidines: Estrogen receptor ligands possessing estrogen receptor β antagonist activity. Journal of Medicinal Chemistry 47(24), 5872-5893 (2004).
2.Chan, K.K.L.,Leung, T.H.Y.,Chan, D.W., et al. Targeting estrogen receptor subtypes (ERα and ERβ) with selective ER modulators in ovarian cancer. Journal of Endocrinology 221(2), 325-336 (2014).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 423.3 |
| 分子式 | C20H11F6N3O |
| CAS号 | 805239-56-9 |
| 稳定性 | ≥ 2 years |
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