| 货号 | 14797-50mg |
| 描述 | L-Sulforaphane is an isothiocyanate derived from the natural compound glucoraphanin, which is abundant in cruciferous vegetables, including broccoli.1 It has powerful antioxidant, anti-inflammatory, and anti-carcinogenic effects.1,2 L-Sulforaphane, at 40 µM, activates nuclear factor erythroid 2-related factor 2- (Nrf2) mediated gene expression by disrupting its association with Kelch-like ECH-associated protein 1 (Keap1), allowing Nrf2 to enter the nucleus to alter transcription.3,4 In this way, sulforaphane induces the expression of phase II detoxification enzymes, which in turn provide diverse beneficial effects.5,1 |
| 别名 | (R)-Sulforaphane; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.James, D.,Devaraj, S.,Bellur, P., et al. Novel concepts of broccoli sulforaphanes and disease: induction of phase II antioxidant and detoxification enzymes by enhanced-glucoraphanin broccoli. Nutrition Reviews 70(11), 654-665 (2012). 2.Liang, H. and Yuan, Q. Natural sulforaphane as a functional chemopreventive agent: Including a review of isolation, purification and analysis methods. Crit.Rev.Biotechnol. 32, 218-234 (2012). 3.La Marca, M.,Beffy, P.,Croce, C.D., et al. Structural influence of isothiocyanates on expression of cytochrome P450, phase II enzymes, and activation of Nrf2 in primary rat hepatocytes. Food and Chemical Toxicology 50(8), 2822-2830 (2012). 4.Dinkova-Kostova, A.T.,Holtzclaw, W.D.,Cole, R.N., et al. Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants. Proceedings of the National Academy of Sciences of the United States of America 99(18), 11908-11913 (2012). 5.Munday, R. and Munday, C.M. Induction of phase II detoxification enzymes in rats by plant-derived isothiocyanates: Comparison of allyl isothiocyanate with sulforaphane and related compounds. Journal of Agricultural and Food Chemistry 52(7), 1867-1871 (2004). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 177.3 |
| 分子式 | C6H11NOS2 |
| CAS号 | 142825-10-3 |
| 稳定性 | ≥ 2 years |
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