| 货号 | 320110-100ug |
| 描述 | Leukotriene B4-d4(LTB4-d4) contains four deuterium atoms at the 6, 7, 14, and 15 positions. It is intended for use as an internal standard for the quantification of LTB4 by GC- or LC-mass spectrometry. LTB4 is a dihydroxy fatty acid derived from arachidonic acid through the 5-lipoxygenase pathway.1,2,3 It promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, enhancement of lysosomal enzyme release, superoxide anion production, chemotaxis, and chemokinesis. In subnanomolar ranges (3.9 x 10−10 M), LTB4 causes chemotaxis and chemokinesis in human PMNL.4 At higher concentrations, (1.0 x 10−7 M), LTB4 leads to neutrophil aggregation and degranulation as well as superoxide anion production.4,5 |
| 别名 | LTB4-d4; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Rådmark, O.,Malmsten, C.,Samuelsson, B., et al. Leukotriene A: Stereochemistry and enzymatic conversion to leukotriene B. Biochemical and Biophysical Research Communications 92, 954-961 (1980). 2.Ford-Hutchinson, A.W.,Bray, M.A.,Doig, M.V., et al. Leukotriene B, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytes. Nature 286, 264-265 (1980). 3.McGee, J., and Fitzpatrick, F. Enzymatic hydration of leukotriene A4. The Journal of Biological Chemisty 260, 12832-12837 (1985). 4.Ford-Hutchinson, A.W. Leukotriene B4 in inflammation. Critical Reviews in Immunology 10, 1-12 (1990). 5.McMillan, R.M., and Foster, S.J. Leukotriene B4 and inflammatory disease. Agents and Actions 24, 114-119 (1988). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥99% deuterated forms (d1-d4) |
| 计算分子量 | 340.5 |
| 分子式 | C20H28D4O4 |
| CAS号 | 124629-74-9 |
| 稳定性 | ≥ 1 year |
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