| 货号 | 18678-25g |
| 描述 | Diminazene is a diamidine that is cytotoxic to protozoa, including Trypanosoma,Babesia, and Cytauxzoon.1,2 Diamidines, including diminazene, affect a variety of enzymes and modulate interactions between nucleic acids and proteins.3 Diminazene inhibits diamine oxidase with a Ki value of 13 nM.3InTrypanosoma, transport proteins are important in the effectiveness of diminazene.4 In rats and in vitro, diminazene enhances the enzymatic activity of angiotensin-converting enzyme 2.5 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Mosqueda, J.,Olvera-Ramírez, A.,Aguilar-Tipacamú, G., et al. Current advances in detection and treatment of Babesiosis. Current Medicinal Chemistry 19(10), 1504-1518 (2012). 2.daSilva Oliveria, G.L., and de Freitas, R.M. Diminazene aceturate-An antiparasitic drug of antiquity: Advances in pharmacology & therapeutics. Pharmacological Research 102, 135-157 (2015). 3.Huang, T.L.,Mayence, A., and Vanden Eynde, J.J. Some non-conventional biomolecular targets for diamidines. A short survey. Bioorganic & Medicinal Chemistry 22(7), 1983-1992 (2014). 4.Munday, J.C.,Settimo, L., and de Koning, H.P. Transport proteins determine drug sensitivity and resistance in a protozoan parasite, Trypanosoma brucei. Front.Pharmacol. 6:32, (2015). 5.Sheony, V.,Gjymishka, A.,Jarajapu, Y.P., et al. Diminazene attenuates pulmonary hypertension and improves angiogenic progenitor cell functions in experimental models. American Journal of Respiration and Critical Care Medicine 187(6), 648-657 (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | 22 |
| 纯度 | ≥98% |
| 计算分子量 | 515.5 |
| 分子式 | C14H15N7 • 2C4H7NO3 |
| CAS号 | 908-54-3 |
| 稳定性 | ≥ 1 year |
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