Indirubin-3-monoxime
货号：
13314-50mg 基本售价：
7980.0 元 规格：
50 mg
产品信息
概述| 货号 | 13314-50mg |
| 描述 | Indirubin-3’-oxime is a potent inhibitor of glycogen synthase kinase 3β (GSK3β; IC50 = 22 nM).1 As GSK3β phosphorylates tau protein, indirubin-3’-oxime prevents tau phosphorylation both in vitroandin vivo at Alzheimer’s disease-relevant sites.1 It also inhibits cyclin-dependent kinases (CDKs) at higher concentrations, including Cdk1/cyclin B (IC50 = 180 nM), Cdk2/cyclin A (IC50 ~500 nM), Cdk2/cyclin E (IC50 = 250nM), Cdk4/cyclin D1 (IC50 = 3.3 µM) and Cdk5/p35 (IC50 = 100 nM). Indirubin-3’-oxime reversibly inhibits the proliferation of many cells types, arresting cycling in the G2/M phase.2,3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.LeClerc, S.,Garnier, M.,Hoessel, R., et al. Indirubins inhibit glycogen synthase kinase-3β and CDK5/P25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer’s disease. A property common to most cyclin-dependent kinase inhibitors? The Journal of Biological Chemisty 276(1), 251-260 (2001).
2.Damiens, E.,Baratte, B.,Marie, D., et al. Anti-mitotic properties of indirubin-3-monoxime, a CDK/GSK-3 inhibitor: Induction of endoreplication following prophase arrest. Oncogene 20, 3786-3797 (2001).
3.Marko, D.,Schätzle, S.,Friedel, A., et al. Inhibition of cyclin-dependent kinase 1 (CDK1) byindirubin derivatives in human tumour cells. British Journal of Cancer 84(2), 283-289 (2001).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 277.3 |
| 分子式 | C16H11N3O2 |
| CAS号 | 160807-49-8 |
| 稳定性 | ≥ 2 years |
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