| 货号 | 18765-25mg |
| 描述 | Epothilones are microtubule-stabilizing agents with potential anti-neoplastic actions.1,2,3 They are natural macrolides that have high potency in both taxane-sensitive and taxane-resistant models.2,3 Epothilone D is a desoxy form of epothilone B (Item No. 10924) that inhibits the growth of a variety of cancer cells both in vitro(IC50 values range from 0.97 to 21 nM) and in mice.3,4 Epothilone D is brain penetrant and reduces neurodegeneration in aged tau transgenic mice.5,6 Effects include improved axonal transport, decreased tau neuropathology, and reduced hippocampal neuron loss.5,6 Epothilone D also rescues microtubule defects and attenuates nigrostriatal degeneration in a mouse model of Parkinson’s disease.4 |
| 别名 | Desoxyepothilone B;NSC 73147; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Bollag, D.M.,McQueney, P.A.,Zhu, J., et al. Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action. Cancer Research 55(11), 2325-2333 (1995). 2.Goodin, S.,Kane, M.P. and Rubin, E.H. Epothilones: Mechanism of action and biologic activity. Journal of Clinical Oncology 22(10), 2015-2025 (2011). 3.Cheng, K.L.,Bradley, T. and Budman, D.R. Novel microtubule-targeting agents - the epothilones. Biologics 2(4), 789-811 (2008). 4.Cartelli, D.,Casagrande, F.,Busceti, C.L., et al. Microtubule alterations occur early in experimental parkinsonism and the microtubule stabilizer epothilone D is neuroprotective. Sci.Rep. 3, (2013). 5.Brunden, K.R.,Zhang, B.,Carroll, J., et al. Epothilone D improves microtubule density, axonal integrity, and cognition in a transgenic mouse model of tauopathy. Journal of Neuroscience 30(41), 13861-13866 (2010). 6.Lou, K.,Yao, Y.,Hoye, A.T., et al. Brain-penetrant, orally bioavailable microtubule-stabilizing small molecules are potential candidate therapeutics for Alzheimer’s disease and related tauopathies. Journal of Medicinal Chemistry 57(14), 6116-6127 (2014). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥99% |
| 计算分子量 | 491.7 |
| 分子式 | C27H41NO5S |
| CAS号 | 189453-10-9 |
| 稳定性 | ≥ 1 year |
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