| 货号 | 18763-25mg |
| 描述 | The family of Bcl-2 proteins plays pivotal roles in either promoting or preventing apoptosis. Bcl-2 family members contain one or more of four characteristic Bcl-2 homology (BH) domains, which are crucial for function. For example, anti-apoptotic Bcl-2 family proteins prevent death signaling by heterodimerizing with pro-death proteins at their BH3 domains.1 BH3I-1 is a cell permeable inhibitor that blocks the binding of BH3 peptides to Bcl-xL, inducing apoptosis.2 It inhibits interactions of BH3 domain-containing proteins with Bcl-xL, Bcl-2, and Bcl-W, inducing apoptosis in Bcl-2 or Bcl-W expressing cells with Ki values of 43.4 and 124 µM, respectively.3,4 BH3I-1 enhances radiation sensitivity in non-small cell lung cancer cells.3 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Ni Chonghaile, T. and Letai, A. Mimicking the BH3 domain to kill cancer cells. Oncogene 27(Suppl 1), S149-S157 (2008). 2.Degterev, A.,Lugovskoy, A.,Cardone, M., et al. Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL. Nat.Cell.Biol. 3(2), 173-182 (2001). 3.Roa, W.,Chen, H.,Alexander, A., et al. Enhancement of radiation sensitivity with BH3I-1 in non-small cell lung cancer. Clin.Invest.Med. 28(2), 55-63 (2005). 4.Porter, J.R.,Helmers, M.R.,Wang, P., et al. Profiling small molecule inhibitors against helix-receptor interactions: The Bcl-2 family inhibitor BH3I-1 potently inhibits p53/hDM2. Chemical Communications 46(42), 8020-8022 (2010). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 400.3 |
| 分子式 | C15H14BrNO3S2 |
| CAS号 | 300817-68-9 |
| 稳定性 | ≥ 2 years |
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