| 货号 | 18168-25mg |
| 描述 | Src family kinases are non-receptor tyrosine kinases with diverse roles in signal transduction and disease.1,2 A-419259 is an inhibitor of Src family kinases, with IC50 values for Src, Lck, Lyn, and Hck of 9, 3, 3, and 0.43 nM, respectively.3,4 It displays at least 1,000-fold selectivity for these enzymes over other kinases. A-419259 induces growth arrest and apoptosis in chronic myelogenous leukemia cell lines.3,4 It prevents differentiation while maintaining pluripotency in embryonic stem cells.5,6 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Liu, S.T.,Pham, H.,Pandol, S.J., et al. Src as the link between inflammation and cancer. Front.Physiol. 4, (2014). 2.Reinecke, J. and Caplan, S. Endocytosis and the Src family of non-receptor tyrosine kinases. Biomol.Concepts 5(2), 143-155 (2014). 3.Wilson, M.B.,Schreiner, S.J.,Choi, H.J., et al. Selective pyrrolo-pyrimidine inhibitors reveal a necessary role for Src family kinases in Bcr-Abl signal transduction and oncogenesis. Oncogene 21(53), 8075-8088 (2002). 4.Pene-Dumitrescu, T.,Peterson, L.F.,Donato, N.J., et al. An inhibitor-resistant mutant of Hck protects CML cells against the antiproliferative and apoptotic effects of the broad-spectrum Src family kinase inhibitor A-419259. Oncogene 27(56), 7055-7069 (2008). 5.Meyn, M.A., III,Schreiner, S.J.,Dumitresco, T.P., et al. SRC family kinase activity is required for murine embryonic stem cell growth and differentiation. Molecular Pharmacology 68(5), 1320-1330 (2005). 6.Zhang, X.,Meyn, M.A., III and Smithgall, T.E. c-Yes tyrosine kinase is a potent suppressor of ES cell differentiation and antagonizes the actions of its closest phylogenetic relative, c-Src. ACS Chemical Biology 9(1), 139-146 (2015). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 592 |
| 分子式 | C29H34N6O • 3HCl |
| CAS号 | 1435934-25-0 |
| 稳定性 | ≥ 2 years |
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