NVP-TAE226
货号：
17685-25mg 基本售价：
7966.0 元 规格：
25 mg
产品信息
概述| 货号 | 17685-25mg |
| 描述 | NVP-TAE226 is an inhibitor of focal adhesion kinase (FAK; IC50 = 5.5 nM) and the related proline-rich tyrosine kinase 2-β (PYK2β; IC50 = 5 nM).1 It can also inhibit the insulin-like growth factor 1 receptor (IC50 = 0.16 µM) as well as the activity of its downstream target genes such as MAPK and Akt.1 NVP-TAE226 has been shown to inhibit glioma and ovarian tumor growth in in vivo tumor models.2 |
| 别名 | TAE226; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Liu, T.-J.,LaFortune, T.,Honda, T., et al. Inhibition of both focal adhesion kinase and insulin-like growth factor-I receptor kinase suppresses glioma proliferation in vitro and in vivo. Mol. Cancer Ther. 6(4), 1357-1367 (2007).
2.Halder, J.,Lin, Y.G.,Merritt, W.M., et al. Therapeutic efficacy of a novel focal adhesion kinase inhibitor TAE226 in ovarian carcinoma. Cancer Research 67(22), 10976-10983 (2007).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 468.9 |
| 分子式 | C23H25ClN6O3 |
| CAS号 | 761437-28-9 |
| 稳定性 | ≥ 2 years |
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