Luotonin F
货号：
14254-25mg 基本售价：
7966.0 元 规格：
25 mg
产品信息
概述| 货号 | 14254-25mg |
| 描述 | Luotonin F is an alkaloid found in the aerial parts of the P. nigellastrum Bunge, a plant used in traditional Chinese medicine for the treatment of rheumatism and various other inflammatory conditions.1 It demonstrates cytotoxicity against leukemia P-388 cells (IC50 = 2.3 µM) through a mechanism that involves stabilizing the DNA topoisomerase I-DNA complex.1,2,3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Liang, J.L.,Cha, H.C. and Jahng, Y. Recent advances in the studies on luotonins. Molecules 16(6), 4861-4883 (2011).
2.Cagir, A.,Jones, S.H.,Gao, R., et al. Luotonin A. A naturally occurring human DNA topoisomerase I poison. Journal of the American Chemical Society 125(45), 13628-13629 (2003).
3.Mussardo, P.,Corda, E.,González-Ruiz, V., et al. Study of non-covalent interactions of luotonin A derivatives and the DNA minor groove as a first step in the study of their analytical potential as DNA probes. Analytical and Bioanalytical Chemistry 400(2), 321-327 (2011).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 301.3 |
| 分子式 | C18H11N3O2 |
| CAS号 | 244616-85-1 |
| 稳定性 | ≥ 2 years |
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