| 货号 | 13828-10mg |
| 描述 | The lysine methyltransferase EZH2 (KMT6), part of the polycomb repressive complex 2, catalyzes trimethylation of lysine 27 on histone H3 and is involved in proliferation and aggressive cell growth associated with neoplastic cells.1 3-Deazaneplanocin A is a cyclopentenyl analog of 3-deazaadenosine, originally synthesized as an inhibitor of S-adenosyl-L-homocysteine hydrolase.2 It has been shown to deplete EZH2 levels and to inhibit trimethylation of lysine 27 on histone H3 in cultured human acute myeloid leukemia (AML) HL-60 and OCI-AML3 cells and in primary AML cells in a dose-dependent manner (0.2-1 μM).3 3-Deazaneplanocin A treatment of cultured human AML cells induces increased expression of the cell-cycle regulators p21, p27, and FBXO32, leading to cell cycle arrest and apoptosis.3 When used in combination with the pan-histone deacetylase inhibitor panobinostat (10 mg/kg), 3-deazaneplanocin A’s (1 mg/kg) antileukemic effects are synergistically enhanced in mice implanted with AML cells.3,4 |
| 别名 | DZNep;NSC 617989; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Simon, J.A. and Lange, C.A. Roles of the EZH2 histone methyltransferase in cancer epigenetics. Mutation Research 647, 21-29 (2008). 2.Tseng, C.K.H.,Marquez, V.E.,Fuller, R.W., et al. Synthesis of 3-deazaneplanocin A, a powerful inhibitor of S-adenosylhomocysteine hydrolase with potent and selective in vitro and in vivo antiviral activities. Journal of Medicinal Chemistry 32, 1442-1446 (1989). 3.Fiskus, W.,Wang, Y.,Sreekumar, A., et al. Combined epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A and the histone deacetylase inhibitor panobinostat against human AML cells. Blood 114(13), 2733-2743 (2009). 4.Bissinger, E.M.,Heinke, R.,Sippl, W., et al. Targeting epigenetic modifiers: Inhibitors of histone methyltransferases. Med.Chem.Commun. (2010). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥97% |
| 计算分子量 | 262.3 |
| 分子式 | C12H14N4O3 |
| CAS号 | 102052-95-9 |
| 稳定性 | ≥ 2 years |
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