WIN 552,12-3 mesylate (50 MG)
货号：
2327/50 基本售价：
7961.3 元 规格：
50 mg
产品信息
概述| 货号 | 2327/50 |
| 别名 | [(3S)-2,3-Dihydro-5-methyl-3-(4-morpholinylmethyl)pyrrolo[1,2,3-de]-1,4-benzoxazin-6-yl]-1-naphthalenyl-methanone monomethanesulfonate; (S)-(-)-WIN 55,212 |
性能| 供应商 | Tocris |
| 生物活性 | Novel, low potency CB2 receptor silent antagonist and CB1 receptor partial inverse agonist. Competitively antagonizes effects of CP 55,940 (pA2 = 6.1) and SR 144528 (pEC50 = 5.3) at CB2 receptors and acts as a partial inverse agonist at CB1 receptors (pIC50 = 5.5). Displays modest activity at human melatonin MT1 and muscarinic M4 receptors, but is selective over several other GPCRs. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 522.61 |
| 分子式 | C27H26N2O3 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO with gentle warming |
| 参考文献 | Savinainenet al (2005) Identification of WIN55212-3 as a competitive neutral antagonist of the human cannabinoid CB2 receptor. Br.J.Pharmacol. 145 636. PMID: 15852035. |
