| 货号 | 5285/50 |
| 别名 | 2-[[2-(2-Bromo-4-methylphenoxy)ethy |
| 供应商 | Tocris |
| 生物活性 | Allosteric AMP-activated protein kinase (AMPK) activator; allosterically stimulates active AMPK heterotrimers, increasing the activity of α1β1γ1 by 1.5-fold and α2β1γ1 by 1.7-fold (EC50 values are 0.42 and 0.95 μM, respectively). Inhibits dephosphorylation of AMPK Thr-172 by PP2Cα. Stimulates glucose uptake and fatty acid oxidation without increasing the ADP/ATP ratio. Also decreases fatty acid synthesis and glucose output in primary hepatocytes. Improves glucose tolerance and decreases cholesterol content in db/dbmice. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 361.69 |
| 分子式 | C13H13BrN2OS.HCl |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Liet al (2013) Novel small-molecule AMPK activator orally exerts beneficial effects on diabetic db/db mice. Toxicol.Appl.Pharmacol. 273 325. PMID: 24055643. Zhanget al (2013) Novel small-molecule AMP-activated protein kinase allosteric activator with beneficial effects in db/db mice. PLoS One 8 e72092. PMID: 23977216. |