| 货号 | 3707/50 |
| 别名 | N-(4-Chloro-3-methoxyphenyl)-2-pyri |
| 供应商 | Tocris |
| 生物活性 | Selective positive allosteric modulator at mGlu4 receptors (EC50 values are 240 and 110 nM at human and rat receptors respectively). Inactive at mGlu1, mGlu2, mGlu3, mGlu6 and mGlu7 receptors and displays weak activity at mGlu5 and mGlu8 receptors. Brain penetrant. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 262.69 |
| 分子式 | C13H11CIN2O2 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 1161205-04-4 |
| 参考文献 | Engerset al (2011) Discovery, synthesis, and structure-activity relationship development of a series of N-(4-Acetamido)phenylpicolinamides as positive allosteric modulators of metabotropic glutamate receptor 4 (mGlu4) with CNS exposure in rats. J.Med.Chem. 54 1106. PMID: 21247167. Engerset al (2009) Synthesis and evaluation of a series of heterobiarylamides that are centrally penetrant metabotropic glutamate receptor 4 (mGluR4) positive allosteric modulators (PAMs). J.Med.Chem. 52 4115. PMID: 19469556. |