| 货号 | 1098/50 |
| 别名 | 2-[[3-(3,4-Dimethoxyphenyl)-1-oxo-2 |
| 供应商 | Tocris |
| 生物活性 | Antiallergic via inhibition of chemical mediator release from mast cells. Shown to be an effective inhibitor of angiogenesis. Demonstrated to antagonize the effects of angiotensin II on human arteries, possibly by an interaction at the level of the AT1 receptor. Inhibits TRPV2-mediated responses; binds to Aβ40 monomers and increases Aβ40 fibrillation. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 327.34 |
| 分子式 | C18H17NO5 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 53902-12-8 |
| 参考文献 | Connorset al (2013) Tranilast binds to Aβ monomers and promotes Aβ fibrillation. Biochemistry. PMID: 23679559. Hisanagaet al (2009) Regulation of calcium-permeable TRPV2 channel by insulin in pancreatic beta-cells. Diabetes. 58 174. PMID: 18984736. Jinet al (1998) Tranilast, an anti-allergic drug, possesses antagonistic potency to angiotensin II. Eur.J.Pharmacol. 361 199. PMID: 9865509. Isajiet al (1997) Tranilast inhibits the proliferation, chemotaxis and tube formation of human microvascular endothelial cells in vitro and angiogenesis in vivo. Br.J.Pharmacol. 122 1061. PMID: 9401770. Hishikawaet al (1996) Tranilast restores cytokine-induced nitric oxide production against platelet derived growth factor in vascular smooth muscle cells. J.Cardiovasc.Pharmacol. 28 200. PMID: 8856474. |