| 货号 | 5197/50 |
| 别名 | 6-Fluoro-N-[(4-Fluorophenyl)methyl] |
| 供应商 | Tocris |
| 生物活性 | Inhibitor of autophagy; inhibits USP10 and USP13 activity (IC50 values are 0.6 and 0.7 μM respectively) and promotes degradation of Vps34 (class III PI 3-kinase) complexes. Selectively promotes apoptosis of cancer cells under starvation conditions. Prevents the PDGF-induced conversion from the contractile to synthetic phenotype in vascular smooth muscle cells. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 271.26 |
| 分子式 | C15H11F2N3 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Salabeiet al (2013) PDGF-mediated autophagy regulates vascular smooth muscle cell phenotype and resistance to oxidative stress. Biochem.J. 451 375. PMID: 23421427. Liuet al (2011) Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13. Cell 147 223. PMID: 21962518. |