| 货号 | 3440/50 |
| 别名 | Ethyl 2-[[2-[2-[(2,3-Dihydro-1,4-benzodio |
| 供应商 | Tocris |
| 生物活性 | Selective steroidogenic factor-1 (SF-1, NR5A1) inhibitor (IC50 values are 0.76, >33 and >33 μM at SF-1, RORα and VP16 respectively). Inhibits SF-1-dependent luciferase expression in HEK 293T cells in vitro(IC50 = 30 nM). |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 452.46 |
| 分子式 | C24H24N2O7 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 868224-64-0 |
| 参考文献 | Madouxet al (2008) Potent, selective and cell penetrant inhibitors of SF-1 by functional ultra-high-throughput screening. Mol.Pharmacol. 73 1776. PMID: 18334597. Rothet al (2008) Synthesis of small molecule inhibitors of the orphan nuclear receptor steroidogenic factor-1 (NR5A1) based on isoquinolinone scaffolds. Bioorg.med.Chem.Lett. 18 2628. PMID: 18374567. |