| 货号 | 1214/50 |
| 别名 | 2-Methyl-6-(2-phenylethenyl)pyridin |
| 供应商 | Tocris |
| 生物活性 | A highly selective non-competitive antagonist for the metabotropic glutamate mGlu5 receptor subtype; displays an IC50 value of 0.3 μM |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 计算分子量 | 195.26 |
| 分子式 | C14H13N |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 6266-99-5 |
| 参考文献 | Mathiesenet al (2003) Positive allosteric modulation of the human metabotropic glutamate receptor 4 (hmGluR4) by SIB-1893 and MPEP. Br.J.Pharmacol. 138 1026. PMID: 12684257. Chapmanet al (2000) Anticonvulsant activity of two metabotropic glutamate group I antagonists selective for the mGlu5 receptor: 2-methyl-6-(phenylethynyl)-pyridine (MPEP), and (E)-6-methyl-2-styryl-pyridine (SIB 1893). Neuropharmacology 39 1567. PMID: 10854901. Varneyet al (1999) SIB-1757 and SIB-1893: selective, noncompetitive antagonists of metabotropic glutamate receptor type 5. J.Pharmacol.Exp.Ther. 290 170. PMID: 10381773. |