| 货号 | 4347/50 |
| 别名 | (9H-Xanthen-9-ylcarbonyl)-carbamic acid butyl ester |
| 供应商 | Tocris |
| 生物活性 | Positive allosteric modulator of mGlu group I receptors (pEC50 value is 7.16 for the rat mGlu1a receptor). Exhibits activity at all group I receptors, including human and rat mGlu1 and rat mGlu5. Enhances the effects of (S)-DHPG in CA3 neurons (EC50 = 95 nM). |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 325.36 |
| 分子式 | C19H19NO4 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Hempstapatet al (2006) A novel class of positive allosteric modulators of metabotropic glutamate receptor subtype 1 interact with a site distinct from that of negative allosteric modulators. Mol.Pharmacol. 70 616. PMID: 16645124. Knoflachet al (2001) Positive allosteric modulators of metabotropic glutamate receptor: Characterizationn, mechanism of action, and binding site. Proc.Natl.Acad.Sci. 98 13402. PMID: 11606768. |