| 货号 | 1862/50 |
| 别名 | 2,2-Bis(hydroxymethyl)-1-azabicyclo |
| 供应商 | Tocris |
| 生物活性 | Selectively restores mutant p53 activity in tumor cells via activation of Bax and PUMA. Induces apoptosis and inhibits growth of tumors with mutant p53. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 185.22 |
| 分子式 | C9H15NO3 |
| 可溶性/溶解性 | Soluble to 100 mM in water |
| CAS号 | 5608-24-2 |
| 参考文献 | Wanget al (2007) PRIMA-1 induces apoptosis by inhibiting JNK signalling but promoting the activation of Bax. Biochem.Biophys.Res.Commun. 352 203. PMID: 17113036. Bykovet al (2002) Restoration of the tumour suppressor function to mutant p53 by a low-molecular-weight compound. Nat.Med. 8 282. PMID: 11875500. Bykovet al (2002) Mutant p53-dependent growth suppression distinguishes PRIMA-1 from known anticancer drugs: a statistical analysis of information in the National Cancer Institute database. Carcinogenesis 23 2011. PMID: 12507923. |