| 货号 | 1093/50 |
| 别名 | 5-methyl-1-phenyl-2(1H)-pyridinone |
| 供应商 | Tocris |
| 生物活性 | Antifibrotic agent, effective in models of pulmonary and lung fibrosis. Inhibits collagen production and fibroblast proliferation. Regulates cytokine levels following oral administration in vivo. Potent scavenger of free radicals and inhibitor of lipid peroxidation. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 185.23 |
| 分子式 | C12H11NO |
| 可溶性/溶解性 | Soluble to 20 mM in water |
| CAS号 | 53179-13-8 |
| 参考文献 | Meiet al (2005) Protection of pirfenidone against an early phase of oleic acid-induced acute lung injury in rats. J.Pharmacol.Exp.Ther. 313 379. PMID: 15608079. Okuet al (2002) Pirfenidone suppresses tumor necrosis factor-α, enhances interleukin-10 and protects mice from endotoxic shock. Eur.J.Pharmacol. 446 167. PMID: 12098599. Iyeret al (1999) Effects of pirfenidone on procollagen gene expression at the transcriptional level in bleomycin hamster model of lung fibrosis. J.Pharmacol.Exp.Ther. 289 211. PMID: 10087006. Kehrer and Margolin (1997) Pirfenidone diminishes cyclophosphamide-induced lung fibrosis in mice. Toxicol.Lett. 90 125. PMID: 9067480. |