PFK 15 (50 MG)
货号：
5339/50 基本售价：
7961.3 元 规格：
50 mg
产品信息
概述| 货号 | 5339/50 |
| 别名 | 1-(4-Pyridinyl)-3-(2-quinolinyl)-2-propen-1-one |
性能| 供应商 | Tocris |
| 生物活性 | Selective PFKFB3 (6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase) inhibitor (IC50 = 207 nM). Selective for PFKFB3 over a panel of 96 other kinases. Reduces glucose uptake and induces apoptosis in H522 lung adenocarcinoma and Jurkat T cell leukemia cells. Suppresses glucose uptake and tumor growth, and inhibits lung metastasis of Lewis lung carcinoma cell xenografts in mice. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >99 % |
| 计算分子量 | 260.29 |
| 分子式 | C17H12N2O |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Clemet al (2013) Targeting 6-phosphofructo-2-kinase (PFKFB3) as a therapeutic strategy against cancer. Mol.Cancer Ther. 12 1461. PMID: 23674815. |
